Abstract: Perinatal depression will endanger pregnant women, families and society. The program for prevention of perinatal depression is targeted at pregnant women and their family members. The intervention goal of preventing and alleviating perinatal depression was achieved by changing two mediating variables, maternal self-efficacy and family support with Baker's depression Self-measurement table, family care scale and maternal self-efficacy scale as measurement tools. The design process of the intervention manual should follow the principles of satisfying individual needs, understanding the objects of intervention, balancing intermediary variables and taking into account the overall environment. With the rise of evidence-based research, social work and psychology will be merged in the field of mental health. On the basis of absorbing psychological theories and methods, social work will look at individual problems from a holistic perspective and devote itself to exerting the potential of others. The social work's value orientation and the pursuit of human welfare will be more in line with the development and progress of society as a whole. At the same time, researchers should pay attention to humanistic concern while respecting the scientific and orderly nature of evidence-based research, so as to promote the further application and development of intervention research in the field of social work.

Key words: intervention manual, program design, perinatal period, depression, treatment principles